CARD¶
What is CARD?¶
The CARD is a rigorously curated collection of known resistance determinants and associated antibiotics, organized by the Antibiotic Resistance Ontology (ARO) and AntiMicrobial Resistance (AMR) gene detection models.
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References:
What is RGI?¶
Resistance Gene Identifier (RGI) predicts antibiotic resistance genes from genome sequence data. The RGI integrates the ARO, bioinformatics models and molecular reference sequence data to broadly analyze antibiotic resistance at the genome level.
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How to access to the Antibiotic Resistance predictions?¶
CARD predictions are available through the Comparative Genomics section, in the main navigation menu.
What are these tables?¶
The table CARD Results, show all hits for all CDS which pass the Perfect or Strict algorithms.
- The Perfect algorithm detects perfect matches to the curated reference sequences and mutations in CARD.
- The Strict algorithm detects previously unknown variants of known AMR genes, including secondary screen for key mutations, using detection models with curated similarity cut-offs to ensure the detected variant is likely a functional AMR gene.
- The Loose algorithm works outside of the detection model cut-offs to provide detection of new, emergent threats and more distant homologs of AMR genes, but will also catalog homologous sequences and spurious partial hits that may not have a role in AMR.
The Xref column can have some accession from PDB (3FTJ), DNAAccession (CM000441.2), PubChem (3021).
The table CARD AB Results, show the antibiotic and the resistance mechanisms for each CDS which may have the resistance.
You can acces the CARD database by clicking on any ARO id